Education

PhD, University of Tennessee, 2011

DVM, Institute of Agriculture (Vietnam), 2000

Research Interest

My research focuses on bacterial pathogenesis, host-pathogen interactions, antimicrobial resistant mechanisms. Multiple bacterial pathogens that are studied include: Salmonella, Francisella, Legionella pneumophila. Additionally, we are developing new therapeutic approaches to counteract intracellular bacterial pathogens. 

Publications

The sensor kinase QseC regulates the unlinked PmrA response regulator and downstream gene expression in Francisella, Ky Van Hoang, James Fitch, Peter White, Nrusingh P. Mohapatra and John S. Gunn. 2020. Journal of Bacteriology 2020 JB.00321-20. doi: 10.1128/JB.00321-20

In Vivo and Cellular Trafficking of Acetalated Dextran Microparticles for Delivery of a Host-Directed Therapy for Salmonella enterica Serovar Typhi Infection Johnson MM, Collier MA, Hoang KV, Pino EN, Graham-Gurysh EG, Gallovic MD, Zahid MSH, Chen N, Schlesinger L, Gunn JS, Bachelder EM, Ainslie KM.Mol Pharm. 2018.  

Complement receptor 3-mediated suppression of the inflammasome by RasGAP during Francisella tularensis infection of human phagocytic cells. Ky V. Hoang, Murugesan V.S. Rajaram, Heather Curry, Mikhail A. Gavrilin, Mark D. Wewers, and Larry S. Schlesinger. Front Immunol. 2018. 4  

In vitro and in vivo susceptibility of Francisella to AR-13, a celecoxib pharmacophore derivative. Ky V. Hoang, Haley E. Adcox, Heather Curry, Larry S. Schlesinger, and John S. Gunn. Front Microbiol. 2017.  

Salmonella extracellular matrix components influence biofilm formation and gallbladder colonization. Haley E. Adcox, Erin M. Vasicek, Varun Dwivedi, Ky V. Hoang, Joanne Turner and John S. Gunn. Infect Immun. 2016.  

Identification of genes required for secretion of the Francisella oxidative burst-inhibiting acid phosphatase AcpA.  Ky Van Hoang, Carolyn G. Lee, Jacob Koopman, Jasmine Moshiri, Haley E. Adcox and John S. Gunn. Front. Microbiol. 2016.  

Needle-free Delivery of Acetalated Dextran Encapsulated AR-12 Significantly Delays Time to Death After Lethal Inhaled Challenge from Francisella tularensis, Ky V. Hoang, Hassan Borteh, Heather Curry, Murugesan V. S. Rajaram, Michael A. Collier, Eric Bachelder, Kristy Ainslie, Larry S. Schlesinger and John S. Gunn. Antimicrob Agents Chemother. 2016.  

Acetalated Dextran Encapsulated AR-12 as a Host-directed Therapy to Control Salmonella Infection. Ky V. Hoang, Hassan M. Borteh, Murugesan V. S. Rajaram, Kevin J. Peine, Heather Curry, Michael A. Collier, Michael L. Homsy, Eric M. Bachelder, John S. Gunn, Larry S. Schlesinger, Kristy M. Ainslie. International Journal of Pharmaceutics, 30 December 2014.  

Development and Stability of Bacteriocin resistance in Campylobacter spp.  K.V. Hoang, N.J. Stern and J. Lin. Journal of Applied Microbiology. 2011.  

Identification of genetic loci that contribute to Campylobacter resistance to fowlicidin-1, a chicken host defense peptide.  Hoang KV, Wang Y, Lin JFront Cell Infect Microbiol. 2012.

Prevalence, development, and molecular mechanisms of bacteriocin resistance in Campylobacter Hoang KV, Stern NJ, Saxton AM, Xu F, Zeng X, Lin J. Appl Environ Microbiol. 2011.  

All Publications in PubMed 

Grant Funding

Development of a host-targeted therapy to control Typhoid Fever and Sepsis, Technology Development Fund Award, Principal Investigator, 09/2020-09/2022

Virulence regulation of small RNAs in Francisella, NIH R21AI140001-01, Co-Investigator ,2019-2021