In the News

LSU VET MED DEAN RECEIVES PRESTIGIOUS BLAINE AWARD

Education

PhD, Royal Veterinary College (London), 1998

BVetMed, Royal Veterinary College (London), 1993

BSc, King's College London, 1990

CASLAT, Imperial College London 

Certifications and Licenses

Diplomate, American College of Veterinary Internal Medicine

Diplomate, European College of Veterinary Internal Medicine-Companion Animals

Fellow, Royal College of Veterinary Surgeons (UK)

Fellow, Higher Education Academy (UK)

Member, Royal College of Veterinary Surgeons (UK)

Fellow, Royal Society for the Encouragement of Arts, Manufactures and Commerce (UK)

Fellow, The College of Physicians of Philadelphia

Research Interest

My research focuses on mechanisms of peripheral tolerance in health and disease, spanning the mouse, rat and dog as model species of both autoimmune disease and cancer. My work has interrogated the role of regulatory T cells and more recently myeloid-derived suppressor cells in this context.

Awards & Honors

Undergraduate awards (BSc and BVetMed): Leaper Science Prize (1987), Frank Drury Anatomy Prize (1989), Tompson First Prize (1992), Centenary First Prize (1992)

British Society for Immunology (BSI) Best Poster Prize (of >400 posters on display), Annual Congress, December 2-5, 2003, Harrogate: Monk, CR, Spachidou, M, Rovis, F, Lechler, RI and Garden, OA (2003) MRL/Mp CD4+CD25- T cells resist suppression by CD25+ Tregs in vitro: a defect of effector cells in lupus? Immunology 110 (S1): 81

ProImmune Ltd Poster Prize, BSI Annual Congress, December 2-5, 2003, Harrogate: Rovis, F, Lee, B, Lechler, RI and Garden, OA (2003) Murine CD4+CD25+ Tregs: towards the identification of molecular markers. Immunology 110 (S1): 119

Nature Immunology Poster Prize, The Third International Conference on Regulatory T Cells and Helper  T  Cell  Subsets  and  Clinical  Applications  in  Human  Diseases,  October  13-16, 2012, Shanghai, China: Pinheiro, D, Pinney, JW and Garden, OA. A phylogenetic examination of regulatory networks within the Animalia Kingdom.

The Kennel Club International Canine Health Award for research into canine health and diseases: May 2017

Publications

Hlavaty, SI, Chang, YM, Orth, RP, Goulian, M, Planet, PJ, Thamm, DH, Punt, JA and Garden, OA (2019) Bacterial killing activity of polymorphonuclear myeloid-derived suppressor cells isolated from tumor-bearing dogs. Frontiers in Immunology 10: 2371; doi: 10.3389/fimmu.2019.02371 

Wu, Y, Chang, YM, Polton, G, Stell, AJ, Szladovits, B, MacFarlane, M, Peters, LM, Priestnall, SL, Bacon, NJ, Kow, K, Stewart, S, Shama, E, Goulart, MR, Gribben, J, Xia, D and Garden, OA (2020) Gene expression profiling of B cell lymphoma in dogs reveals dichotomous metabolic signatures distinguished by oxidative phosphorylation. Frontiers in Oncology 10: 307; doi: 10.3389/fonc.2020.00307 

Stark, AK, Davenport, ECM, Patton, DT, Scudamore, CL, Vanhaesebroeck, B, Veldhoen, M, Garden, OA and Okkenhaug, K (2020) Loss of PI3K activity in regulatory T cells leads to neuronal inflammation. Journal of Immunology 205(1): 78-89 

Ambrosini, YM, Borcherding, DC, Seo, Y-J, Segarra, S, Glanemann, B, Garden, OA, Neuber, S, Muller, U, Dang, VD, Borts, D, Atherly, T, Willette, A, Jergens, AE, Mochel, JP and Allenspach, K (2020) Treatment with hydrolyzed diet supplemented with prebiotics and glycosaminoglycans alters lipid metabolism in canine inflammatory bowel disease. Frontiers in Veterinary Science 7: 451; doi 10.3389/fvets.2020.00451 

Wu, Y, Chang, YM, Lawson, BS, Galban, EM, Mittelman, NS, Benedicenti, L, Petesch, SC, Carroll, AB, Punt, JA, Luo, J and Garden, OA (2021) Myeloid-derived suppressor cell and regulatory T cell frequencies in canine myasthenia gravis: A pilot study. The Veterinary Journal 267: 105581; doi 10.106/j.tvjl.2020.105581

Klotsman, M, Coquery, S, Sathyan, G, Naageshwaran, V, Shivanand, P, Fairchild, AJ, Garden, OA and Anderson, WH (2021) Pharmacokinetics and pharmacodynamics of immediate and extended-release mycophenolic acid preparations in healthy beagle dogs. Frontiers in Veterinary Science 7: 611404; doi 10.3389/fvets.2020.611404 

Barr, CA, Alvarado, F, Chang, YM, Luo, J and Garden, OA (2021) The impact of alfaxalone, propofol and ketamine on canine peripheral blood lymphocyte cytotoxicity in vitro. Research in Veterinary Science 136: 182-184 

Leopardi, V, Chang, YM, Pham, A, Luo, J and Garden, OA (2021) A systematic review of the potential implication of infectious agents in myasthenia gravis. Frontiers in Neurology 12: 618021; doi 10.3389/fneur.2021.618021 

Forgash, JT, Chang, YM, Mittelman, NS, Petesch, S, Benedicenti, L, Galban, E, Hammond, JJ, Glass, EN, Barker, JR, Shelton, GD, Luo, J and Garden, OA (2021) Clinical features and outcome of acquired myasthenia gravis in 94 dogs. Journal of Veterinary Internal Medicine 35(5): 2315-2326; doi 10.1111/jvim.16223 

Glanemann, B, Seo, YJ, Priestnall, SL, Garden, OA, Kilburn, L, Rossoni-Serao, M, Segarra, S, Mochel, JP and Allenspach, K (2021) Clinical efficacy of prebiotics and glycosaminoglycans versus placebo in dogs with food responsive enteropathy receiving a hydrolyzed diet: A pilot study. PLOS ONE 16(10): e0250681; doi 10.1371/journal.pone.0250681 

All Publications on PubMed